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S-(+)-Mecamylamine hydrochloride

Names

[ CAS No. ]:
107596-30-5

[ Name ]:
S-(+)-Mecamylamine hydrochloride

[Synonym ]:
(1S,3S,4R)-N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine,hydrochloride

Biological Activity

[Description]:

S-(+)-Mecamylamine (hydrochloride) is a neuronal nicotinic receptor modulator with antidepressant activity.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[References]

[1]. Lippiello PM, Beaver JS, Gatto GJ, et al. TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther. 2008;14(4):266-277.

[2]. Vieta E, Thase ME, Naber D, et al. Efficacy and tolerability of flexibly-dosed adjunct TC-5214 (dexmecamylamine) in patients with major depressive disorder and inadequate response to prior antidepressant. Eur Neuropsychopharmacol. 2014;24(4):564-574.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₂ClN

[ Molecular Weight ]:
203.75200

[ Exact Mass ]:
203.14400

[ PSA ]:
12.03000

[ LogP ]:
3.61350

Related Compounds