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SF 2312

Names

[ CAS No. ]:
107729-45-3

[ Name ]:
SF 2312

Biological Activity

[Description]:

SF2312, a natural phosphonate Antibiotic (Antibiotic), is a highly potent Enolase (Enolase) inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Enolase
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

SF2312 对 ENO1 缺失的神经胶质瘤细胞具有选择性毒性。SF2312 在低 μM 范围内抑制 ENO1 缺失的 D423 神经胶质瘤细胞系的增殖 (处理 2 周)，而同基因 ENO1 拯救的 D423 细胞，异位再表达 ENO1 仅在 SF2312 浓度高于 200 μM 时显示增殖抑制。SF2312 (10 μM) 以剂量依赖性方式减少 U-13C 葡萄糖向 13C 乳酸的转化，其方式对 ENO1 缺失优于 ENO1 拯救或其他 ENO1 -完整的神经胶质瘤细胞[1]。 SF2312 由放线菌小单孢菌产生，对多种细菌均有活性，对沙门氏菌和葡萄球菌活性强，对大肠杆菌活性弱，对真菌无活性[1]。

[References]

[1]. Paul G Leonard, et al. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec;12(12):1053-1058.  

Chemical & Physical Properties

[ Molecular Formula ]:
C4H8NO6P

[ Molecular Weight ]:
197.08300

[ Exact Mass ]:
197.00900

[ PSA ]:
128.11000

Related Compounds