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AVP-786

Names

[ CAS No. ]:
1079043-55-2

[ Name ]:
AVP-786

[Synonym ]:
Morphinan, 17-(methyl-d3)-3-(methyl-d3-oxy)-, (9α,13α,14α)-
UNII:427476LZFT
3-[(2H3)methoxy]-17-[(2H3)methyl]-ent-morphinan
Deudextromethorphan
427476LZFT
CTP-786
DEXTROMETHORPHAN D6
(9α,13α,14α)-17-(2H3)Methyl-3-[(2H3)methyloxy]morphinan
10288
d6-DM

Biological Activity

[Description]:

Deudextromethorphan (AVP-786) is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Khoury R, et al. AVP-786 as a promising treatment option for Alzheimer's Disease including agitation. Expert Opin Pharmacother. 2021 May;22(7):783-795.

[2]. Garay RP, et al. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132.

[3]. Hecking J, et al. Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders. Chronic Stress (Thousand Oaks). 2021 Jun 2;5:24705470211020446.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
394.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H19D6NO

[ Molecular Weight ]:
277.434

[ Flash Point ]:
116.2±30.2 °C

[ Exact Mass ]:
277.231262

[ LogP ]:
4.11

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.585

Related Compounds