fibronectin type iii connecting segment fragment 1-25

Names

[ Name ]:
fibronectin type iii connecting segment fragment 1-25

[Synonym ]:
CS1 peptide
Fibronectin connecting segment 1
FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1

Biological Activity

[Description]:

Fibronectin Type III Connecting Segment Fragment 1-25 is a peptide that is responsible for melanoma cell adhesion, and plays an important role in development of the peripheral nervous system in chicken[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. A Komoriya, et al. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J Biol Chem. 1991 Aug 15;266(23):15075-9.

[2]. M J Humphries, et al. Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment. J Cell Biol. 1988 Apr;106(4):1289-97.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂₃H₁₉₅N₃₁O₃₉

[ Molecular Weight ]:
2732.05000

[ Exact Mass ]:
2730.42000

[ PSA ]:
1071.20000

[ LogP ]:
0.50740

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats.

Endocr. J. 55(2) , 373-9, (2008)

To compare the effects of postprandial hypertriglyceridemia and postprandial hyperglycemia on monocyte adhesion to endothelial cells, we investigated the effects of twice-daily standard diet (5% fat) ...

Fibronectin-alpha4beta1 integrin interactions modulate p42/44 MAPK phosphorylation in steatotic liver cold ischemia-reperfusion injury.

Transplant. Proc. 37(1) , 432-4, (2005)

We investigated the effects of the connecting segment-1 (CS1) peptide, which blocks fibronectin (FN)-alpha4beta1 integrin interactions upon cell signaling, leukocyte migration, and secretion of proinf...

Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta.

Arterioscler. Thromb. Vasc. Biol. 26(10) , 2275-80, (2006)

The aim of this study was to elucidate the effect of repetitive fluctuations in blood glucose concentrations on monocyte adhesion to the aortic endothelium.Nonobese type 2 diabetes, Goto-Kakizaki (GK)...