<Suppliers Price>

Z-Phe-Phe-FMK

Names

[ CAS No. ]:
108005-94-3

[ Name ]:
Z-Phe-Phe-FMK

[Synonym ]:
zff-fmk
z-ff-fmk
cathepsin l inhibitor i
Cathepsin L-IN-2

Biological Activity

[Description]:

Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. Jonathan Frew, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 Mar 16;15(1):21.

[2]. Kirsi Ravanko, et al. Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts. Cancer Res. 2004 Dec 15;64(24):8831-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H27FN2O4

[ Molecular Weight ]:
462.51

[ Exact Mass ]:
462.19500

[ PSA ]:
84.50000

[ LogP ]:
4.57200

Related Compounds