3,6-Dihydroxyflavone

Names

[ Name ]:
3,6-Dihydroxyflavone

[Synonym ]:
3,6-dihydroxy-flavone
2-phenyl-3,6-dihydroxy-4-benzopyrone
MFCD00143082
3,6-dihydroxy-2-phenyl-4-benzopyrone
6-Hydroxyflavonol

Biological Activity

[Description]:

3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Chang H, et al. 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway. Eur J Pharmacol. 2010;648(1-3):31-38.

Chemical & Physical Properties

[ Density]:
1.472g/cm3

[ Boiling Point ]:
477.1ºC at 760 mmHg

[ Melting Point ]:
231-234ºC

[ Molecular Formula ]:
C₁₅H₁₀O₄

[ Molecular Weight ]:
254.24

[ Flash Point ]:
186.2ºC

[ Exact Mass ]:
254.05800

[ PSA ]:
70.67000

[ LogP ]:
2.87120

[ Vapour Pressure ]:
6.55E-10mmHg at 25°C

[ Index of Refraction ]:
1.712

[ Water Solubility ]:
Soluble in water.

MSDS

Click to get detail MSDS

Safety Information

[ WGK Germany ]:
3

[ HS Code ]:
2914400090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%