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(D-Phe12,Leu14)-Bombesin

Names

[ CAS No. ]:
108437-88-3

[ Name ]:
(D-Phe12,Leu14)-Bombesin

[Synonym ]:
L-Leucinamide, 5-oxo-L-prolyl-L-glutaminyl-L-arginyl-L-leucylglycyl-L-asparaginyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-D-phenylalanyl-L-leucyl-
GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-DPHE-LEU-LEU-NH2
PYR-QRLGNQWAVGFLL-NH2
2-Methyl-5-hydroxytryptamine hydrochloride
5-Oxo-L-prolyl-L-glutaminyl-L-arginyl-L-leucylglycyl-L-asparaginyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-D-phenylalanyl-L-leucyl-L-leucinamide
PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-LEU-NH2
PGLU-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-D-PHE-LEU-LEU-NH2
GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-DPHE-LEU-LEU-NH2: GLP-QRLGNQRAVG-DF-LL-NH2
(D-Phe12,Leu14)-Bombesin
[D-Phe12, Leu14]-Bombesin

Biological Activity

[Description]:

[D-Phe12,Leu14]-Bombesin is an antagonist of Bombesin Receptor. [D-Phe12,Leu14]-Bombesin can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor

[References]

[1]. Di Bello C, et al. Conformation studies on bombesin receptor antagonists: 500 MHz NMR and CD characterization of synthetic (D-Phe12, Leu14)-bombesin. Biochem Biophys Res Commun. 1989 Jun 30;161(3):987-93.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C75H114N22O18

[ Molecular Weight ]:
1611.84

[ Exact Mass ]:
1610.868164

[ PSA ]:
657.45000

[ LogP ]:
-1.75

[ Index of Refraction ]:
1.660

[ Storage condition ]:
-20°C

Related Compounds