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Florfenicol amine hydrochloride

Names

[ CAS No. ]:
108656-33-3

[ Name ]:
Florfenicol amine hydrochloride

[Synonym ]:
Florfenicol Amine Hydrochloride

Biological Activity

[Description]:

Florfenicol amine hydrochloride is a metabolite of Florfenicol (HY-B1374). Florfenicol inhibits bacterial protein synthesis by binding to 50S and 70S subunits in the ribosome to abolish the activity of peptidyltransferase. Florfenicol, is a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. B-K Park, et al. Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus). J Vet Pharmacol Ther. 2006 Feb;29(1):37-40.  

[2]. Anadón A, et al. Plasma and tissue depletion of florfenicol and florfenicol-amine in chickens. J Agric Food Chem. 2008 Nov 26;56(22):11049-56.  

Chemical & Physical Properties

[ Melting Point ]:
162-164ºC

[ Molecular Formula ]:
C10H15ClFNO3S

[ Molecular Weight ]:
283.75

[ Exact Mass ]:
283.04500

[ PSA ]:
88.77000

[ LogP ]:
3.00340

Related Compounds