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Eupalinolide K

Names

[ CAS No. ]:
108657-10-9

[ Name ]:
Eupalinolide K

[Synonym ]:
2-Butenoic acid, 4-hydroxy-2-methyl-, (3aR,4S,6Z,9S,10Z,11aR)-2,3,3a,4,5,8,9,11a-octahydro-9-hydroxy-6,10-dimethyl-3-methylene-2-oxocyclodeca[b]furan-4-yl ester, (2E)-
3β-hydroxy-8β-[4'-hydroxytigloyloxy]costunolide
(2E)-4-hydroxy-2-methylbut-2-enoic acid (3aR,4R,6E,9S,10E,11aR)-2,3,3a,4,5,8,9,11a-octahydro-9-hydroxy-6,10-dimethyl-3-methylene-2-oxocyclodeca[b]furan-4-yl ester
(3aR,4S,6Z,9S,10Z,11aR)-9-Hydroxy-6,10-dimethyl-3-methylene-2-oxo-2,3,3a,4,5,8,9,11a-octahydrocyclodeca[b]furan-4-yl (2E)-4-hydroxy-2-methyl-2-butenoate
eupalinolide K

Biological Activity

[Description]:

Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) [1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Signaling Pathways >> JAK/STAT Signaling >> STAT
Research Areas >> Others

[Target]

STAT3


[References]

[1]. Yang B, , et al. Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer. Nat Prod Res. 2019 Feb;33(4):477-485.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
574.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H26O6

[ Molecular Weight ]:
362.417

[ Flash Point ]:
201.5±23.6 °C

[ Exact Mass ]:
362.172943

[ PSA ]:
93.06000

[ LogP ]:
2.29

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.557

Related Compounds