Metallo β-lactamase ligand 1

Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent[1]. The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells[1].

After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate[1].

[1]. Arakawa, Yoshichika, et al.β-LACTAMASE INHIBITOR. WO2019221122A1.