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CGS 12066B dimaleate

Names

[ CAS No. ]:
109028-10-6

[ Name ]:
CGS 12066B dimaleate

[Synonym ]:
c-JUN peptide
CGS 12066B dimaleate,7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxalinedimaleate

Biological Activity

[Description]:

CGS 12066 (dimaleate) dimaleate is a selective 5-HT1B receptor agonist with an IC50 of 51 nM[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1B Receptor:51 nM (IC50)


[References]

[1]. Neale RF, et al. Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur J Pharmacol. 1987 Apr 7;136(1):1-9.

Chemical & Physical Properties

[ Boiling Point ]:
419.3ºC at 760 mmHg

[ Molecular Formula ]:
C25H25F3N4O8

[ Molecular Weight ]:
566.48300

[ Flash Point ]:
207.4ºC

[ Exact Mass ]:
566.16200

[ PSA ]:
172.98000

[ LogP ]:
2.68460

[ Vapour Pressure ]:
3.08E-07mmHg at 25°C

Related Compounds