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SK 609

Names

[ CAS No. ]:
1092797-77-7

[ Name ]:
SK 609

[Synonym ]:
Benzenepropanamine, 2-chloro-α-methyl-, hydrochloride (1:1)
4-(2-Chlorophenyl)-2-butanamine hydrochloride (1:1)

Biological Activity

[Description]:

SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation; reverses akinesia and reduces L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson's desease.

[References]

References 1. Marshall CA, et al. Neuropharmacology. 2019 Jan 8. pii: S0028-3908(19)30002-4. 2. Xu W, et al. ACS Chem Neurosci. 2017 Mar 15;8(3):486-500. 3. Kuzhikandathil EV, et al. Pharm Res. 2012 Aug;29(8):2264-75. View Related Products by Target Dopamine Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C10H15Cl2N

[ Molecular Weight ]:
220.139

[ Exact Mass ]:
219.058151


Related Compounds