β-S-ARCA

Names

[ Name ]:
β-S-ARCA

Biological Activity

[Description]:

β-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Warminski M, et al. Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 Feb 19;16(2):334-343.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₁N₁₀O₁₇P₃S

[ Molecular Weight ]:
832.52

β-S-ARCA

Names

Biological Activity

Chemical & Physical Properties

Related Compounds