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Ezetimibe-d4

Names

[ CAS No. ]:
1093659-89-2

[ Name ]:
Ezetimibe-d4

[Synonym ]:
Ezetimibe-d4

Biological Activity

[Description]:

Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

[3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H17D4F2NO3

[ Molecular Weight ]:
413.45

[ Exact Mass ]:
413.17400

[ PSA ]:
60.77000

[ LogP ]:
4.95330

Related Compounds