Deupirfenidone

Names

[ CAS No. ]:
1093951-85-9

[ Name ]:
Deupirfenidone

[Synonym ]:
d3-5-(methyl)-1-phenylpyridine-2(1H)-one
5-(methyl-d3)-1-phenylpyridin-2(1H)-one

Biological Activity

[Description]:

Deupirfenidone-d3-d3 is the deuterium labeled Pirfenidone (HY-B0673)[1].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-243.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H8D3NO

[ Molecular Weight ]:
188.24000

[ Exact Mass ]:
188.10300

[ PSA ]:
22.00000

[ LogP ]:
2.14590