Fmoc-His(Trt)-OH

Names

[ Name ]:
Fmoc-His(Trt)-OH

[Synonym ]:
MFCD00043332
N-Fmoc-N'-Trityl-L-Histidine
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine
N-alpha-FMOC-N-Trityl-L-histidine
EINECS 439-640-4
Nα-Fmoc-N(im)-trityl-L-histidine
Na-Fmoc-Nim-trityl-L-histidine
Fmoc-His(Trt)-OH
Nα-[(9H-Fluoren-9-ylMethoxy)carbonyl]-tele-(triphenylMethyl)-L-histidine
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine,
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-
Nα-Fmoc-τ-trityl-L-histidine
Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine

Biological Activity

[Description]:

Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
811.7±65.0 °C at 760 mmHg

[ Melting Point ]:
150-155 °C(lit.)

[ Molecular Formula ]:
C₄₀H₃₃N₃O₄

[ Molecular Weight ]:
619.708

[ Flash Point ]:
444.7±34.3 °C

[ Exact Mass ]:
619.247131

[ PSA ]:
93.45000

[ LogP ]:
8.03

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.

Biopolymers 104 , 116-27, (2015)

The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino aci...

New amphiphilic N-phosphoryl oligopeptides designed for gene delivery.

Int. J. Pharm. 468(1-2) , 83-90, (2014)

Gene therapy is a potent tool for the treatment of cancer and other gene defect diseases, which involves using DNA that encodes a functional, therapeutic gene to replace a mutated gene. However, the D...