RX 821002 hydrochloride

[Description]:

2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2)[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[In Vivo]

2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement[3].

[References]

[1]. Head GA. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. Ann N Y Acad Sci. 1995;763:531-540.

[2]. Trendelenburg AU, et al. Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1996;353(3):245-249.

[3]. Sandner G, et al. Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion. Front Behav Neurosci. 2014;8:15. Published 2014 Jan 28.

[ Molecular Formula ]:
C₁₂H₁₅ClN₂O₃

[ Molecular Weight ]:
270.71200

[ Exact Mass ]:
270.07700

[ PSA ]:
52.08000

[ LogP ]:
1.36860

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

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