Triflupromazine hydrochloride

Names

[ Name ]:
Triflupromazine hydrochloride

[Synonym ]:
Triflupromazine HCl
Fluorofen
N,N-Dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]-1-propanamine hydrochloride (1:1)
Nivoman
Trifluopromazine hydrochloride
N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine,hydrochloride
flupromazine hydrochloride
N,N-Dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine hydrochloride (1:1)
10-[3-(Dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine hydrochloride
N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine hydrochloride
Phenothiazine, 10-(3-dimethylaminopropyl)-2-(trifluoromethyl)-, hydrochloride
Fluopromazinhydrochlorid
Vesprin hydrochloride
Neoprin
Flumazin
MFCD00058103
Phenothiazine, 10-[3- (dimethylamino)propyl]-2-(trifluoromethyl)-, monohydrochloride
Triflupromazine monohydrochloride
EINECS 214-149-6
Triflupromazine hydrochloride
10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, hydrochloride (1:1)
triflupromazine

Biological Activity

[Description]:

Triflupromazine hydrochloride is an antipsychotic medication, which are Dopamine D1/D2 receptor antagonists.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
427.6ºC at 760 mmHg

[ Melting Point ]:
174.0 to 179.0 °C

[ Molecular Formula ]:
C₁₈H₂₀ClF₃N₂S

[ Molecular Weight ]:
388.878

[ Flash Point ]:
212.4ºC

[ Exact Mass ]:
388.098785

[ PSA ]:
31.78000

[ LogP ]:
6.12680

[ Vapour Pressure ]:
1.62E-07mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO8925000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 1098-60-8

LAST UPDATED :: 199012

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H19-F3-N2-S.Cl-H

MOLECULAR WEIGHT :: 388.91

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1 EXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 254 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory obstruction Blood - hemorrhage

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - species unspecified Kidney

DOSE/DURATION :: 10 mg/L

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,617,1970

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H312 + H332

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P261-P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
UN 2811 6

[ WGK Germany ]:
3

[ RTECS ]:
SO8925000

[ Packaging Group ]:
III