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Deoxycytidine triphosphate trisodium salt

Names

[ CAS No. ]:
109909-44-6

[ Name ]:
Deoxycytidine triphosphate trisodium salt

[Synonym ]:
((2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyltriphosphoric acid,trisodium salt
2'-DEOXYCYTIDINE-5'-TRIPHOSPHORIC ACID TRISODIUM SALT
Dctp-Na3
CYTIDINE 5''-(TETRAHYDROGEN TRIPHOSPHATE),2''-DEOXY-,TRISODIUM SALT
Trisodium 2'-deoxy-5'-O-[({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphinato]cytidine
Deoxycytidine-5'-Triphosphoric Acid Trisodium Sal
Cytidine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate), sodium salt (1:3)
DCTP (SODIUM SALT)
2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE (SODIUM SALT)
MFCD00080336
dCTP,3Na

Biological Activity

[Description]:

Deoxycytidine triphosphate trisodium salt (dCTP trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing[1][2][3].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Metabolic Disease

[In Vitro]

Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-β-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2′-Deoxycytidine-5′-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C[1]. Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate[2].

[References]

[1]. A W Harris, et al. Effect of thymidine on the sensitivity of cultured mouse tumor cells to 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1979 Feb;39(2 Pt 1):538-41.

[2]. B A Bladergroen, et al. CTP:phosphoethanolamine cytidylyltransferase. Biochim Biophys Acta. 1997 Sep 4;1348(1-2):91-9.

[3]. M H Tattersall, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975 Apr;5(2):191-202.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H13N3Na3O13P3

[ Molecular Weight ]:
533.102

[ Exact Mass ]:
532.935425

[ PSA ]:
288.11000

[ LogP ]:
0.71300

[ Storage condition ]:
2-8℃

Related Compounds