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taurohyodeoxycholic acid sodium salt

Names

[ CAS No. ]:
110026-03-4

[ Name ]:
taurohyodeoxycholic acid sodium salt

[Synonym ]:
SODIUM TAUROHYODEOXYCHOLATE
Sodium taurohyodeoxycholate hydrate
Sodium 2-{[(3α,5β,6α)-3,6-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate
Ethanesulfonic acid, 2-[[(3α,5β,6α)-3,6-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
taurohyodeoxycholic acid sodium hydrate

Biological Activity

[Description]:

Taurodeoxychloic Acid (sodium hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxychloic Acid (sodium hydrate) is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

Caspase-12


[In Vivo]

Taurodeoxychloic Acid (TUDCA) is neuroprotective in a transgenic animal model of Huntington’s disease[2].

[References]

[1]. Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601.

[2]. Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6.

Chemical & Physical Properties

[ Melting Point ]:
168ºC (dec.)(lit.)

[ Molecular Formula ]:
C26H47NNaO7S+

[ Molecular Weight ]:
540.71

[ Exact Mass ]:
521.278687

[ PSA ]:
135.14000

[ LogP ]:
4.52640

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-37

[ Safety Phrases ]:
22-36

[ WGK Germany ]:
3

Related Compounds