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ALLM

Names

[ CAS No. ]:
110115-07-6

[ Name ]:
ALLM

[Synonym ]:
N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxo-2-butanyl]-L-leucinamide
N-AC-LEU-LEU-METHIONINAL
AC-LEU-LEU-L-METHIONINAL
L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-
Ac-Leu-Leu-Met-al
N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxobutan-2-yl]-L-leucinamide
ALLM
AC-LEU-LEU-MET-ALDEHYDE
AC-LEU-LEU-METHIONINAL
AC-LEU-LEU-MET-CHO
N-ACETYL-LEU-LEU-MET-CHO
MFCD00065506
AC-LLM-CHO

Biological Activity

[Description]:

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
Research Areas >> Neurological Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[In Vivo]

ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2]. ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2]. Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2] Dosage: 0.05, 0.5, and 2.5 mg/kg Administration: Intraperitoneally; every 24 h for 1 week Result: Showed significantly better motor function.

[References]

[1]. Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18(2):272-9.

[2]. Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22(3):398-406.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
676.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H35N3O4S

[ Molecular Weight ]:
401.564

[ Flash Point ]:
362.9±31.5 °C

[ Exact Mass ]:
401.234833

[ PSA ]:
129.67000

[ LogP ]:
2.64

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.496

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Very slightly soluble (0.52 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

Related Compounds