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Anti-inflammatory agent 8

Names

[ CAS No. ]:
1103920-19-9

[ Name ]:
Anti-inflammatory agent 8

Biological Activity

[Description]:

Anti-inflammatory agent 8 (compound 13) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 8 expresses activity on COX-2 enzyme more than COX-1 with an IC50 of 0.09 nM. Anti-inflammatory agent 8 is orally active[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H15N5OS2

[ Molecular Weight ]:
381.47

Related Compounds