28-Oxooligomycin A

Names

[ Name ]:
28-Oxooligomycin A

[Synonym ]:
28-Oxooligomycin A
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone, 22-ethyl-5',6'-dihydro-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27R,28R,29S)-
Oligomycin B
Oligomycin A,28-oxo
Oligomycin B fromStreptomyces diastatochromogenes
28-oxo-oligomycin A
(1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27R,28R,29S)-22-Ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-5',6'-dihydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,3',9,13(4'H)-tetrone

Biological Activity

[Description]:

Oligomycin B is an antibiotic isolated from marine Streptomyces, used as an eukaryotic ATP synthase inhibitor, induces apoptosis[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase

Signaling Pathways >> Anti-infection >> Bacterial

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
911.4±65.0 °C at 760 mmHg

[ Melting Point ]:
160-161℃

[ Molecular Formula ]:
C₄₅H₇₂O₁₂

[ Molecular Weight ]:
805.046

[ Flash Point ]:
260.3±27.8 °C

[ Exact Mass ]:
804.502380

[ PSA ]:
197.12000

[ LogP ]:
5.50

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.547

[ Storage condition ]:
−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RK3330000

CHEMICAL NAME :: Oligomycin B

CAS REGISTRY NUMBER :: 11050-94-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C45-H72-O12

MOLECULAR WEIGHT :: 805.17

WISWESSER LINE NOTATION :: T6-26- A COX GOV NV RV IU WU B&UTJ A1 E1 K1 L1 M1 O1 PQ Q1 SQ S1 TQ U1 D&2 D-& BT6OXVTJ E1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 80,6092,1958

Safety Information

[ Hazard Codes ]:
Xn: Harmful;T: Toxic;

[ Risk Phrases ]:
20/21/22-68/20/21/22-22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
RK3330000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)