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Psammaplin A

Names

[ CAS No. ]:
110659-91-1

[ Name ]:
Psammaplin A

[Synonym ]:
3-(3-Bromo-4-hydroxy-phenyl)-N-[2-(2-{3-(3-bromo-4-hydroxy-phenyl)-2-[(Z)-hydroxyimino]-propionylamino}-ethyldisulfanyl)-ethyl]-2-[(Z)-hydroxyimino]-propionamide
Li0061
bisprasin
psammaplin A

Biological Activity

[Description]:

Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC
Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.9 nM (DAC1)[1]


[References]

[1]. Matthias G J Baud, et al. Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A Against Its Epigenetic Targets. J Med Chem. 2012 Feb 23;55(4):1731-50.

[2]. Psammaplin A, a Natural Bromotyrosine Derivative From a Sponge, Possesses the

Chemical & Physical Properties

[ Molecular Formula ]:
C22H24Br2N4O6S2

[ Molecular Weight ]:
664.38700

[ Exact Mass ]:
661.95000

[ PSA ]:
214.44000

[ LogP ]:
4.46400

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds