PCB No 157(Aroclor 1254) solution

Names

[ Name ]:
PCB No 157(Aroclor 1254) solution

[Synonym ]:
1,1'-Biphenyl, 2,3,3',4,4'-pentachloro-
2,3,3',4,4'-Pentachloro-1,1'-biphenyl
2,3,3',4,4'-Pentachlorobiphenyl

Biological Activity

[Description]:

Arochlor 1254 is a polychlorinated biphenyl (PCB) mixture with biphenyl and 54% chlorine. Aroclor 1254 reduced cell viability and induced overproduction of intracellular reactive oxygen species in a dose-dependent manner. Arochlor 1254 exposure reduces calcium homeostasis, osteoblast differentiation and bone formation[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[References]

[1]. R D Kimbrough, et al. Morphological changes in livers of rats fed polychlorinated biphenyls: light microscopy and ultrastructure. Arch Environ Health. 1972 Nov;25(5):354-64.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
392.2±37.0 °C at 760 mmHg

[ Melting Point ]:
95.86°C (estimate)

[ Molecular Formula ]:
C₁₂H₅Cl₅

[ Molecular Weight ]:
326.433

[ Flash Point ]:
193.6±23.9 °C

[ Exact Mass ]:
323.883392

[ LogP ]:
6.36

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.620

[ Storage condition ]:
room temp

[ Stability ]:
Stable. Highly flammable. Incompatible with strong oxidizing agents. Attacks some forms of plastics and rubber.

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H304-H315-H336-H373-H410

[ Precautionary Statements ]:
P210-P273-P301 + P310-P331-P370 + P378-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F,Xn,N,T

[ Risk Phrases ]:
11-38-50/53-65-67-33-62-51/53-48/20-36/37/38-22-39/23/24/25-23/24/25-40-37/38-20/21/22-45

[ Safety Phrases ]:
9-16-29-33-60-61-62-35-36/37-36-26-45-7-23-53

[ RIDADR ]:
2315

[ RTECS ]:
TQ1360000

[ Packaging Group ]:
II

Articles

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Arch. Toxicol. 89 , 2413-27, (2015)

Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicatin...

Enormous PCBs increase in oysters from the coast of Guangdong, China

Mar. Pollut. Bull. 62(6) , 1333-6, (2011)

Highlights ► PCB concentrations (ngg−1 d.w.) ranged from 30 to 2040 with a mean of 315 in 2003–2007. ► Annual PCB levels were 313, 290, 342ngg−1 d.w., respectively in 2003, 2006, 2007. ► Recent PCB le...

Transcriptome-wide gene expression in a rat model of attention deficit hyperactivity disorder symptoms: rats developmentally exposed to polychlorinated biphenyls.

Am. J. Med. Genet. B. Neuropsychiatr. Genet. 156B(8) , 898-912, (2011)

Polychlorinated biphenyls (PCB) exposure in rodents provides a useful model for the symptoms of Attention deficit hyperactivity disorder (ADHD). The goal of this study is to identify genes whose expre...