DIF-1

Names

[ Name ]:
DIF-1

[Synonym ]:
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
Dif-1 (dictyostelium)
Morphogen differentiation inducing factor (dictyostelium)
1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexane-1-one
1-(3,5-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-Hexanone
DIF-1
differentiation-inducing factor-1
C13H16Cl2O4

Chemical & Physical Properties

[ Density]:
1.325g/cm3

[ Boiling Point ]:
434.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₆Cl₂O₄

[ Molecular Weight ]:
307.17000

[ Flash Point ]:
216.5ºC

[ Exact Mass ]:
306.04300

[ PSA ]:
66.76000

[ LogP ]:
4.17620

[ Vapour Pressure ]:
3.77E-08mmHg at 25°C

[ Index of Refraction ]:
1.56

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca(2+) and H(+) concentrations in Dictyostelium discoideum.

Dev. Growth Differ. 49(3) , 253-64, (2007)

Differentiation-inducing factors (DIFs) are required for stalk cell formation in Dictyostelium discoideum. In the present study, in order to support our hypothesis that DIFs may function via increases...

A specific pathway inducing autophagic cell death is marked by an IP3R mutation.

Autophagy 4(3) , 349-50, (2008)

Three main advantages make Dictyostelium a very favorable model to study the induction of autophagic cell death in vitro. First, its small, sequenced and haploid genome facilitates genetic approaches....

Autophagic or necrotic cell death in the absence of caspase and bcl-2 family members.

Biochem. Biophys. Res. Commun. 363(3) , 536-41, (2007)

How is one to investigate autophagic or necrotic cell death in the absence of interference from the apoptosis machinery? In the protist Dictyostelium, a model for the study of these two cell death typ...