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RU-301

Names

[ CAS No. ]:
1110873-99-8

[ Name ]:
RU-301

Biological Activity

[Description]:

RU-301 is a pan-TAM receptor inhibitor, exerts pan-TAM inhibitory activity by binding at the interface between Gas6 and the Ig1 domain of the respective TAMs with Kd and IC50 values of 12 μM and 10 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor

[Target]

IC50: 10 μM (TAM)[1]


[References]

[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19F3N4O4S

[ Molecular Weight ]:
480.46

Related Compounds