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IAXO-102

Names

[ CAS No. ]:
1115270-63-7

[ Name ]:
IAXO-102

Biological Activity

[Description]:

IAXO-102 is a TLR4 antagonist, inhibits MAPK and p65 NF-kB phosphorylation involved in down regulation of the expression of TLR4 and TLR4 dependent proinflammatory protein. IAXO-102 prevents experimental abdominal aortic aneurysm development[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Cancer

[Target]

TLR4


[References]

[1]. Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H71NO5

[ Molecular Weight ]:
585.94

Related Compounds