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Fmoc-Phe-Lys(Trt)-PAB

Names

[ CAS No. ]:
1116085-98-3

[ Name ]:
Fmoc-Phe-Lys(Trt)-PAB

Biological Activity

[Description]:

Fmoc-Phe-Lys(Trt)-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C56H54N4O5

[ Molecular Weight ]:
863.05

Related Compounds