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AZ 12799734

Names

[ CAS No. ]:
1117684-36-2

[ Name ]:
AZ 12799734

[Synonym ]:
4-({4-[(2,6-Dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide
Benzenesulfonamide, 4-[[4-[(2,6-dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]-
4-({4-[(2,6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl}amino)benzenesulfonamide

Biological Activity

[Description]:

AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM, inhibits receptor-mediated phosphorylation of SMAD1 by ALK1, BMPR1A and BMPR1B and phosphorylation of SMAD2 by ALK4, TGFBR1 and ALK7; inhibits TGFβ-induced migration in HaCaT cells.

[References]

References 1. Spender LC, et al. Mol Pharmacol. 2018 Nov 20. pii: mol.118.112946. doi: 10.1124/mol.118.112946. 2. Goldberg FW, et al. J Med Chem. 2009 Dec 10;52(23):7901-5. View Related Products by Target TGF beta Receptor (TGFBR)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
554.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H18N4O3S

[ Molecular Weight ]:
370.426

[ Flash Point ]:
288.9±32.9 °C

[ Exact Mass ]:
370.109955

[ LogP ]:
3.91

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.641

Related Compounds