JNc-440
Names
[ CAS No. ]:
1119503-63-7
[ Name ]:
JNc-440
[Synonym ]:
2-Quinazolinecarboxamide, N-[3-[(2,2-diphenylacetyl)amino]propyl]-4-hydroxy-
N-{3-[(Diphenylacetyl)amino]propyl}-4-oxo-1,4-dihydro-2-quinazolinecarboxamide
Biological Activity
[Description]:
JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3; shows affinity for both TRPV4 and KCa2.3, enhances vasodilation and exerts antihypertensive effects in mice.
[References]
References 1. He D, et al. EMBO Mol Med. 2017 Sep 12. pii: e201707725. View Related Products by Target TRP Channel
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Molecular Formula ]:
C26H24N4O3
[ Molecular Weight ]:
440.494
[ Exact Mass ]:
440.184845
[ LogP ]:
2.23
[ Index of Refraction ]:
1.656