Tebufelone

Names

[ CAS No. ]:
112018-00-5

[ Name ]:
Tebufelone

[Synonym ]:
4-(5'-hexynoyl)-2,6-di-tert-butylphenol
Tebufelone
Tebufelonum [INN-Latin]
5-Hexyn-1-one,1-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)
Tebufelona
Tebufelone [USAN:INN]
Tebufelonum
Tebufelona [INN-Spanish]
4-(5'-hexynoyl)-2,6-di-t-butylphenol

Biological Activity

[Description]:

Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

Research Areas >> Neurological Disease

[Target]

COX-2

5-LO

[References]

[1]. S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63.

[2]. Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206.

Chemical & Physical Properties

[ Density]:
0.992g/cm3

[ Boiling Point ]:
383.6ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₈O₂

[ Molecular Weight ]:
300.43500

[ Flash Point ]:
163.8ºC

[ Exact Mass ]:
300.20900

[ PSA ]:
37.30000

[ LogP ]:
4.97340

[ Vapour Pressure ]:
1.97E-06mmHg at 25°C

[ Index of Refraction ]:
1.515