SMPT

Names

[ Name ]:
SMPT

[Synonym ]:
1-({4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoyl}oxy)pyrrolidine-2,5-dione
SMPT
2,5-Pyrrolidinedione,1-((4-(1-(2-pyridinyldithio)ethyl)benzoyl)oxy)

Biological Activity

[Description]:

SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
547ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₁₆N₂O₄S₂

[ Molecular Weight ]:
388.46100

[ Flash Point ]:
284.6ºC

[ Exact Mass ]:
388.05500

[ PSA ]:
127.17000

[ LogP ]:
3.74180

[ Vapour Pressure ]:
5.11E-12mmHg at 25°C

[ Index of Refraction ]:
1.675