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Dynole 34-2

Names

[ CAS No. ]:
1128165-88-7

[ Name ]:
Dynole 34-2

[Synonym ]:
3-Pyridinecarboxylicacid,2-cyano
2-cyanonicotinic acid
Pyridin-2-cyano-3-carbonsaeure
2-cyano-3-pyridinecarboxylic acid

Biological Activity

[Description]:

Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage[1]. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cytoskeleton >> Dynamin

[References]

[1]. Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10(9):1553-62.

[2]. Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52(12):3762-73.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H36N4O

[ Molecular Weight ]:
408.58000

[ Exact Mass ]:
408.28900

[ PSA ]:
64.55000

[ LogP ]:
5.81698

Related Compounds