<Suppliers Price>

Linopirdine dihydrochloride

Names

[ CAS No. ]:
113168-57-3

[ Name ]:
Linopirdine dihydrochloride

[Synonym ]:
1-Phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride
1-Phenyl-3,3-bis(4-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one dihydrochloride
2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-, hydrochloride (1:2)
MFCD06245587

Biological Activity

[Description]:

Linopirdine (DUP-996) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo. Alzheimer Disease Phase 1 Discontinued

[References]

References 1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. 2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3. 3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. View Related Products by Target Potassium Channel Alzheimer Disease

Chemical & Physical Properties

[ Molecular Formula ]:
C26H21N3O.2HCl

[ Molecular Weight ]:
464.386

[ Exact Mass ]:
463.121826

[ Storage condition ]:
2-8°C

Related Compounds