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PPPA

Names

[ CAS No. ]:
113190-92-4

[ Name ]:
PPPA

[Synonym ]:
Neuromedin S (rat)
cis-4-(3-phosphonoprop-1-yl)piperidine-2-carboxylic acid
(2R*,4S*)-4-(3-PHOSPHONOPROPYL)-2-PIPERIDINECARBOXYLIC ACID
2-Piperidinecarboxylic acid,4-(3-phosphonopropyl)-,cis

Biological Activity

[Description]:

PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Benveniste M, Mayer ML. Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor competitive antagonists. Mol Pharmacol. 1992 Oct;42(4):679-86.

[2]. Feng B, et al. The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology. 2005 Mar;48(3):354-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H18NO5P

[ Molecular Weight ]:
251.21700

[ Exact Mass ]:
251.09200

[ PSA ]:
116.67000

[ LogP ]:
0.72590

Related Compounds