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Rivaroxaban D4

Names

[ CAS No. ]:
1132681-38-9

[ Name ]:
Rivaroxaban D4

[Synonym ]:
BAY 59-7939-d4
5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl-d4]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
Rivaroxaban-d4
[2H4]-Rivaroxaban

Biological Activity

[Description]:

Rivaroxaban D4 (BAY 59-7939 D4) is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent，selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM)[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[Target]

IC50: 0.7 nM (Factor Xa); Ki: 0.4 nM (Factor Xa)[1][2]


[References]

[1]. Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48(19)

[2]. Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3(3):514-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14D4ClN3O5S

[ Molecular Weight ]:
439.90600

[ Exact Mass ]:
439.09100

[ PSA ]:
116.42000

[ LogP ]:
3.04080

[ Storage condition ]:
2-8°C

Related Compounds