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ABT-072

Names

[ CAS No. ]:
1132936-00-5

[ Name ]:
ABT-072

[Synonym ]:
Methanesulfonamide, N-[4-[(E)-2-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]ethenyl]phenyl]-
N-(4-{(E)-2-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]vinyl}phenyl)methanesulfonamide
PSQ4R5K1QI

Biological Activity

[Description]:

ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[In Vitro]

ABT-072 inhibits non-nucleoside NS5B polymerase, and yields antiviral effects[1].

[Cell Assay]

To determine compound efficacy, HCV replicon cells are plated at a density of 104 per well in 96-well plates in DMEM media containing 10% FBS. Following incubation overnight, compounds serially diluted in DMSO, or DMSO alone, are added to individual wells to a final DMSO concentration of 0.5%. Cell plates are then incubated at 37°C. for 3 days prior to assaying for cytotoxicity and HCV inhibition. Cell viability is measured using an Alamar Blue assay and CC50 values are calculated using the median effect equation.

[References]

[1]. Min Gao, et al. Combinations of Hepatitis C Virus Inhibitors. US 20120196794 A1


[Related Small Molecules]

Asunaprevir | Sofosbuvir | Simeprevir | Ledipasvir | paritaprevir | Artemisinin | Elbasvir | NIM811 | MK-5172 | velpatasvir | Ombitasvir | Danoprevir (ITMN-191) | Glecaprevir | Celgosivir (hydrochloride) | Alisporivir

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C24H27N3O5S

[ Molecular Weight ]:
469.553

[ Exact Mass ]:
469.167145

[ LogP ]:
3.64

[ Index of Refraction ]:
1.625

[ Storage condition ]:
2-8℃

Related Compounds