Levocetirizine-d4

Names

[ CAS No. ]:
1133210-23-7

[ Name ]:
Levocetirizine-d4

[Synonym ]:
Acetic acid, 2-[[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethyl-1,1,2,2-d4]oxy]-
{[2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}(2H4)ethyl]oxy}acetic acid

Biological Activity

[Description]:

Levocetirizine-d4 ((R)-Cetirizine-d4) is the deuterium-labeled Levocetirizine (HY-B0814)[1]. Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
542.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H21D4ClN2O3

[ Molecular Weight ]:
392.91

[ Flash Point ]:
281.6±28.7 °C

[ Exact Mass ]:
392.180481

[ LogP ]:
2.16

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.589