Pedunculagin

Names

[ CAS No. ]:
113866-64-1

[ Name ]:
Pedunculagin

[Synonym ]:
2,3,4,6-bis-(S)-HHDP-D-glucose
.pedunculagin

Biological Activity

[Description]:

Pedunculagin is a potent 5α-reductase type 1 inhibitor. Pedunculagin inhibits nitric oxide (NO), IL-6, IL-8 production. Pedunculagin decreases the protein expression of 5α-reductase. Pedunculagin shows anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5 alpha Reductase
Research Areas >> Inflammation/Immunology

[In Vitro]

Pedunculagin 在 RAW 246.7 细胞 中抑制一氧化氮 (NO) 的产生，IC50 值为 53.52 µM[1]。 Pedunculagin 在 HaCaT 细胞中抑制 IL-6、IL-8 的产生，IC50 分别为 6.59、0.09 µM[1]。 Pedunculagin (25, 50, 100 µM; 24 h) 降低 HaCaT 细胞中 5α-还原酶的蛋白表达[1]。 Western Blot Analysis[1] Cell Line: HaCaT cells Concentration: 25, 50, 100 µM Incubation Time: 24 h Result: Decreased the 5α-reductase protein expression in a dose-dependent manner.

[References]

[1]. Kim M, et al. Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5α-Reductase Inhibition. Molecules. 2020 May 5;25(9):2154.  

Chemical & Physical Properties

[ Molecular Formula ]:
C34H24O22

[ Molecular Weight ]:
784.54100

[ Exact Mass ]:
784.07600

[ PSA ]:
377.42000

[ LogP ]:
0.66540

Precursor & DownStream

Precursor

DownStream