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PVZB-1194

Names

[ CAS No. ]:
1141768-04-8

[ Name ]:
PVZB-1194

[Synonym ]:
3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide
[1,1'-Biphenyl]-4-sulfonamide, 3'-fluoro-4'-(trifluoromethyl)-
3'-Fluoro-4'-(Trifluoromethyl)biphenyl-4-Sulfonamide

Biological Activity

[Description]:

PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.

[References]

References 1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. 2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36. View Related Products by Target Kinesin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
417.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H9F4NO2S

[ Molecular Weight ]:
319.275

[ Flash Point ]:
206.0±31.5 °C

[ Exact Mass ]:
319.029022

[ LogP ]:
3.26

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.536

Related Compounds