A3AR antagonist 2

Names

[ CAS No. ]:
1144161-05-6

[ Name ]:
A3AR antagonist 2

Biological Activity

[Description]:

A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

hA3:4.54 nM (Ki)

[References]

[1]. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand?Receptor Modeling StudiesJ. Med. Chem., 2009, 52 (8), pp 2407-2419

[2]. Vittoria Colotta, et al. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies. J. Med. Chem. 2009, 52, 8, 2407-2419.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₆N₆O₃

[ Molecular Weight ]:
412.40100

[ Exact Mass ]:
412.12800

[ PSA ]:
106.90000

[ LogP ]:
3.07330

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds