N-Boc-cis-4-hydroxy-D-proline methyl ester

Names

[ Name ]:
N-Boc-cis-4-hydroxy-D-proline methyl ester

[Synonym ]:
1-O-tert-butyl 2-O-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
Methyl Cis-1-Boc-4-Hydroxy-D-Prolinate
N-Boc-cis-4-hydroxy-D-proline methyl ester

Biological Activity

[Description]:

N-Boc-cis-4-hydroxy-D-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-D-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.216g/cm3

[ Boiling Point ]:
335.2ºC at 760mmHg

[ Melting Point ]:
80 °C

[ Molecular Formula ]:
C₁₁H₁₉NO₅

[ Molecular Weight ]:
245.27200

[ Flash Point ]:
156.6ºC

[ Exact Mass ]:
245.12600

[ PSA ]:
76.07000

[ LogP ]:
0.46760

[ Appearance of Characters ]:
Powder | White

[ Vapour Pressure ]:
8.47E-06mmHg at 25°C

[ Index of Refraction ]:
1.5

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%