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Ciwujianoside C3

Names

[ CAS No. ]:
114906-74-0

[ Name ]:
Ciwujianoside C3

[Synonym ]:
.oleanolic acid α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(1->4)-O-β-gentiobiosyl ester
3-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(1-4)-O-β-D-glucopyranosyl-(1-6)-O-β-D-glucopyranosyl ester of oleanolic acid
.3-O-α-L-arabinopyranosyl-oleanolic acid 28-O-α-L-rhamnopyranosyl-(1->4)-β-D-gentiobiosyl ester
.3β-O-α-L-arabinopyranosylolean-12-en-28-O-α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranoside
.oleanolic acid-3-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1-6)-O-β-D-glucopyranoside

Biological Activity

[Description]:

Ciwujianoside C3, an orally active and brain penetrated compound, is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology

[In Vitro]

Cell Viability Assay[1] Cell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Has no effect on cell cytotoxicity and inhibits NO production Western Blot Analysis[1] Cell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Decreases p-ERK and p-JNK expression. RT-PCR[1] Cell Line: RAW 264.7 cells Concentration: 10 µM, 20 µM and 40 µM Incubation Time: 24 hours Result: Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner.

[In Vivo]

Animal Model: Mice[1] Dosage: 0.5 mg/kg Administration: Oral administration; 0.5 mg/kg/day; 17 days Result: Reinforced object recognition memory.

[References]

[1]. Kang DH, et al. Anti‑inflammatory effects of Ciwujianoside C3, extracted from the leaves of Acanthopanax henryi (Oliv.) Harms, on LPS‑stimulated RAW 264.7 cells.Mol Med Rep. 2016 Oct;14(4):3749-58.

[2]. https://www.ncbi.nlm.nih.gov/pubmed/31121888

Chemical & Physical Properties

[ Density]:
1.43±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C53H86O21

[ Molecular Weight ]:
1059.24000

[ Exact Mass ]:
1058.57000

[ PSA ]:
333.67000

[ Storage condition ]:
2-8°C

Precursor & DownStream

Precursor

DownStream

Related Compounds