MK-3901

Names

[ Name ]:
MK-3901

Biological Activity

[Description]:

MK-3901 is a potent, selective, orally active P2X3 antagonist with IC50 of 21 nM; demonstrates efficacy similar to that of naproxen, after 60 mg/kg (p.o.) administration with EC90 of approximately 3 uM in the rat CFA model of inflammatory pain.

[References]

References 1. Ginnetti AT, et al. Bioorg Med Chem Lett. 2018 May 1;28(8):1392-1396. View Related Products by Target P2X Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₄FN₅O₂

[ Molecular Weight ]:
481.531

Related Compounds

MK-8245
MK-8745
MK-0812 Succinate
MK-6240 Precursor
MK-8666
MK-3577
1-[4-(Methoxymethyl)phenyl]cyclopropane-1-carbaldehyde
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
3-(3-bromo-2,2-dimethylpropyl)-2-methyl-2H-indazole
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine