arg-pro-pro-gly-phe-ser-pro-leu acetate salt

Names

[ Name ]:
arg-pro-pro-gly-phe-ser-pro-leu acetate salt

[Synonym ]:
arg-pro-pro-gly-phe-ser-pro-leu acoh 3h2o

Biological Activity

[Description]:

Des-Arg9-[Leu8]-Bradykinin acetate is potent bradykinin receptor 1 (B1R) antagonist. Des-Arg9-[Leu8]-Bradykinin acetate can be used for renal fibrosis research[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

[Target]

IC50: B1R[1]

[References]

[1]. Ji-Zhe Jin, et al. Exogenous pancreatic kininogenase protects against renal fibrosis in rat model of unilateral ureteral obstruction. Acta Pharmacol Sin. 2020 Dec;41(12):1597-1608.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₃H₆₇N₁₁O₁₂

[ Molecular Weight ]:
930.06

[ Exact Mass ]:
929.49700

[ PSA ]:
360.08000

[ LogP ]:
0.84570

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Upregulation of B1 receptor mediating des-Arg9-BK-induced rat paw oedema by systemic treatment with bacterial endotoxin.

Br. J. Pharmacol. 117 , 793-798, (1996)

1. The effect of pretreatment with bacterial endotoxin (LPS, 10 micrograms, i.v., 24 h) on the bradykinin B1 and B2 receptor-induced oedema in the rat paw, and the interaction of B1-mediated responses...

Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade.

Hypertension 48 , 942-949, (2006)

It has been suggested that the effects of angiotensin II type 1 receptor (AT1R) blockers are in part because of angiotensin II type 2 receptor (AT2R) signaling. Interactions between the AT2R and kinin...

The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice.

Neuropharmacology 54 , 597-604, (2008)

The peripheral injection of phorbol myristate acetate (PMA) into the mouse paw induces nociception mediated through activation of protein kinase C (PKC). In the present study, we examine the contribut...