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19(S)-HETE

Names

[ CAS No. ]:
115461-40-0

[ Name ]:
19(S)-HETE

[Synonym ]:
5,8,11,14-Eicosatetraenoic acid, 19-hydroxy-, (5Z,8Z,11Z,14Z,19S)-
19(S)-HETE
(5Z,8Z,11Z,14Z,19S)-19-Hydroxy-5,8,11,14-icosatetraenoic acid

Biological Activity

[Description]:

19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[In Vitro]

19(S)-HETE (1 μM; 15 min) 剂量依赖性诱导 cAMP 在 MEG-01 细胞中增加，EC50 值为 520 nM[1]。 19(S)-HETE (1 μM-1 M) 剂量依赖性地激活环前列腺素受体，EC50 值为 567 nM[1]。 19(S)-HETE (10 μM-1 M) 取代 3H-iloprost，在表达的环前列腺素受体的 COS-1 细胞，Ki 值为 660 nM[1]。 19(S)-HETE (3 μM) 可松弛动脉血管，抑制血小板活化[1]。

[References]

[1]. Tunaru S, et al. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS One. 2016 Sep 23;11(9):e0163633.  

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
477.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H32O3

[ Molecular Weight ]:
320.466

[ Flash Point ]:
256.6±25.2 °C

[ Exact Mass ]:
320.235138

[ PSA ]:
57.53000

[ LogP ]:
4.79

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.514

Related Compounds