Phenglutarimid

Names

[ Name ]:
Phenglutarimid

[Synonym ]:
ATURBANE
Aturban
3-(2-Diaethylamino-aethyl)-3-phenyl-piperidin-2,6-dion
3-(2-Diethylaminoethyl)-3-phenyl-piperidin-2,6-dion
2-(2-(Diethylamino)ethyl)-2-phenylglutarimide
Einecs 214-587-8
3-(2'-(N,N-diethylamino)ethyl)-3-phenylpiperidine-2,6-dione
GLUTARIMIDE,2-((2-DIETHYLAMINO)ETHYL)-2-PHENYL
3-(2-diethylamino-ethyl)-3-phenyl-piperidine-2,6-dione
Phenglutarimid

Biological Activity

[Description]:

Phenglutarimid is an anticholinergic used as an antiparkinsonian agent.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[Target]

anticholinergic[1]

[References]

[1]. BATTEGAY R. [Aturban (phenglutarimide), a new therapeutic drug for parkinsonism; comparative investigation on the therapy of parkinsonism].

Chemical & Physical Properties

[ Density]:
1.072g/cm3

[ Boiling Point ]:
447.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₄N₂O₂

[ Molecular Weight ]:
288.38500

[ Flash Point ]:
224.6ºC

[ Exact Mass ]:
288.18400

[ PSA ]:
49.41000

[ LogP ]:
2.42170

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA4130000

CHEMICAL NAME :: Glutarimide, 2-(2-(diethylamino)ethyl)-2-phenyl-

CAS REGISTRY NUMBER :: 1156-05-4

BEILSTEIN REFERENCE NO. :: 0270870

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H24-N2-O2

MOLECULAR WEIGHT :: 288.43

WISWESSER LINE NOTATION :: T6VMVTJ D2N2&2 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,255,1961

Safety Information

[ HS Code ]:
2925190090

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%