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PPTN

Names

[ CAS No. ]:
1160271-30-6

[ Name ]:
PPTN

[Synonym ]:
4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthoic acid trifluoroacetate (1:1)
4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid trifluoroacetate salt
2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-, compd. with 2,2,2-trifluoroacetic acid (1:1)
PPTN trifluoroacetate salt

Biological Activity

[Description]:

PPTN is a potent, highly specific amtagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays; exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM; inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

[References]

References 1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168. 2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68. 3. Kiselev E, et al. ACS Chem Biol. 2014 Dec 19;9(12):2833-42. 4. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9. View Related Products by Target P2Y Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C29H24F3NO2

[ Molecular Weight ]:
589.525

[ Exact Mass ]:
589.168762

Related Compounds