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(5E)-BiMatoprost

Names

[ CAS No. ]:
1163135-95-2

[ Name ]:
(5E)-BiMatoprost

[Synonym ]:
4-Androstene-3,17-dione-19-ol
15R-bimatoprost
19-hydroxyandrostenedione
4-androsten-19-ol-3,17-dione
(5E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamide
(5E)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
19-Hydroxyandrostendione
5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5E)-
19-Hydroxy-androst-4-en-3,17-dion
15-epi-bimatoprost
19-Hydroxy-4-androstene-3,17-dione
5-trans bimatoprost

Biological Activity

[Description]:

5,6-trans-Bimatoprost is the inactive isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Signaling Pathways >> Others >> Others

[References]

[1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55(1):22-7.  

[2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
629.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H37NO4

[ Molecular Weight ]:
415.57

[ Flash Point ]:
334.7±31.5 °C

[ Exact Mass ]:
415.272247

[ PSA ]:
89.79000

[ LogP ]:
1.98

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.591

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds